Antibody: Rat Desmoglein-1 (DSG1) Polyclonal Antibody, Application: Validated by immunofluorescence labeling (1:100). Design: Retrospective study. ncbi gi num : 119703744. ncbi acc num : NP_001933.2. © Copyright 2021 R&D Systems, Inc. All Rights Reserved. Objective: To assess the predictive value of anti-desmoglein (Dsg) 1 and anti-Dsg3 antibody (Ab) enzyme-linked immunosorbent assay (ELISA) values for the occurrence of relapses in pemphigus. ncbi mol weight : … Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Desmoglein 1/DSG1 antibody [EPR6766(B)] (ab124798) ab124798, at a 1/250 dilution, staining Desmoglein 1/DSG1 in … Desmoglein‑1 in Human Skin Hyperplasia. The diagnosis of pemphigus depends on biopsy and serum studies that characterize lesions and … Recombinant Human Desmoglein‑1 Fc Chimera (Catalog #. Reconstructed human epidermis tissues were embedded in paraffin. Each Desmoglein-1 Antibody is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. products description : Mouse monoclonal Desmoglein 1 antibody. Test Details. Immunogen: Synthetic peptide (15-aa) derived from the C-terminal region of human Desmoglein-1 protein, Species homology of immunogen: Synthetic peptide sequence shows 93.3% homology to mouse or rat sequence, Storage buffer: PBS, pH 7.2, 0.1% sodium azide. These antibodies bind to calcium dependent adhesion molecules in cell surface desmosomes, notably desmoglein 1(DSG-1) in pemphigus foliaceus and desmoglein 3 (DSG-3) in pemphigus vulgaris. uniprot acc num : Q02413. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents. Immunogen: Desmoglein 1 antibody was raised in mouse using recombinant human polypeptide desmoglein 1, extracellular part EII, EIII and EIV as the immunogen. Pemphigus vulgaris patients with both mucosal and skin lesions have antibodies to both DSG-3 and DSG-1. Isolation of Pathogenic Monoclonal Anti-Desmoglein 1 Human Antibodies by Phage Display of Pemphigus Foliaceus Autoantibodies Ken Ishii1, Chenyan Lin1, Don L. Siegel2 and John R. Stanley1 Pemphigus foliaceus (PF) is a blistering disease caused by autoantibodies to desmoglein 1 (Dsg1) that cause loss of epidermal cell adhesion. (Based on 2 Reviews), $25/€18/£15/$25CAN/Â¥75 Yuan/Â¥1250 Yen for a review with an image, $10/€7/£6/$10 CAD/Â¥70 Yuan/Â¥1110 Yen for a review without an image. Cat. Antibody dilution 1:50, works also at 1:100 dilution. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally. Many patients with pemphigus foliaceus, a superficial form of pemphigus have antibodies to DSG1. VAT, excl. 2 Antibodies to desmoglein 1 (DSG1) and desmoglein 3 (DSG3) have been shown to be present in patients with pemphigus. General Protocols Desmoglein 1 and 3 IgG antibodies IndicationSuspicion of autoimmune skin disease, e.g. Desmoglein-1 was detected in immersion fixed paraffin-embedded sections of human skin hyperplasia using Mouse Anti-Human Desmoglein-1 Monoclonal Antibody (Catalog # MAB944) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC001). Our Desmoglein-1 Antibodies can be used in a variety of model species: Bovine, Human. Anti-Mouse HRP-DAB Cell & Tissue Staining Kit, 19 Citations, VisUCyte Antigen Retrieval Reagent-Universal, VisUCyte Antigen Retrieval Reagent-Acidic, 2 Citations, 13 Citations, 8 Citations, Antigen Retrieval Reagent Sampler (50 mL each), 7 Citations, 1 Image, 42 Citations, Mouse F(ab)2 IgG (H+L) PE-conjugated Antibody, 12 Citations, Rat Anti-Mouse IgG2A PerCP-conjugated Antibody, 56 Citations, Donkey Anti-Mouse IgG NorthernLights™ NL557-conjugate Antibody, Rat Anti-Mouse IgG2A PE-conjugated Antibody, Goat Anti-Mouse IgG Biotinylated Antibody, 4 Citations, Mouse F(ab)2 IgG (H+L) APC-conjugated Antibody, Mouse F(ab)2 IgG (H+L) Fluorescein-conjugated Antibody, 5 Citations, Donkey Anti-Mouse IgG NorthernLights™ NL493-conjugated Antibody, 6 Citations, Mouse/Rabbit IgG VisUCyte HRP Polymer Antibody, 1 Citations, 2 Images, Rat Anti-Mouse IgG2A APC-conjugated Antibody, Donkey Anti-Mouse IgG Biotinylated Antibody, 11 Citations, Donkey Anti-Mouse IgG NorthernLights™ NL637-conjugated Antibody, Goat Anti-Mouse IgG Fc Affinity Purified Polyclonal Ab, 3 Citations, Mouse F(ab)2 IgG (H+L) PerCP-conjugated Antibody. Patients with pemphigus vulgaris, a deeper form of pemphigus, have antibodies to DSG3 and sometimes DSG1 as well. Decreased diagnostic sensitivity and specificity when testing for pemphigus compared with Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG . The diagnosis of pemphigus depends on biopsy and serum studies that characterize lesions and … We offer a 100% guarantee on all our products. Reconstitute at 0.5 mg/mL in sterile PBS. To better understand PF pathophysiology, we used phage … Paraffin was removed by successive baths of xylene and ethanol; then, antigen was retrieved using citrate. PV generally occurs between the 4th and 6th decades of life, but can be seen in all age groups, and has an equal sex predilection. Aseptically collect 5-8 mL of blood by approved venipuncture procedures. $290.00. Allow the blood to clot at room temperature (20-25° C) and separate as soon as possible to limit hemolysis. Instead of having the HAV adhesion motif found in type I cadherins, Desmoglein-1 has R/YAL as the adhesion motif on its amino-terminal cadherin repeat. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. Many patients with pemphigus foliaceus, a superficial form of pemphigus have antibodies to DSG1. Desmoglein-1 is one of three members of the desmoglein subfamily of calcium-dependent cadherin cell adhesion molecules. Br J Dermatol. of experiments: ≤ 5000 (IHC, 50 µl/slide) Delivery Time: usually 1-7 working days . Circulating IgG antibodies to desmoglein-1 and -3 (Dsg1, Dsg3) adhesion molecules of squamous epithelial cells are the underlying defects, causing loss of cell-to-cell adhesion. 12 months from date of receipt, -20 to -70 °C as supplied. Pemphigus vulgaris patients with both mucosal and skin lesions have antibodies to both DSG-3 and DSG-1. These desmoglein gene family members are located in a cluster on chromosome 18. Customer Support: customercare@bicellscientific.com, Technical Issues: tech@bicellscientific.com, Validated Antibodies – The Foundation of Biomedical Research. Consider ordering with Epithelial Cell Surface Antibody IgG . Buffers Expand BLOCK Solution  NaCl 8 gKCl 0.2 gNa2HPO4 1.44 gKH2PO4 […], Antibody: Rabbit VE-cadherin (Cdh5 or Cadherin-5 or CD144) Polyclonal Antibody, Antibody: Rabbit Anti-Claudin-10 (CLDN10) Polyclonal Antibody, Antibody: Rabbit Anti-ZO-1 (Tjp1) (N-terminus) polyclonal antibody. Antibody titer correlates in a semiquantitative manner with … Harman KE(1), Seed PT, Gratian MJ, Bhogal BS, Challacombe SJ, Black MM. Not for use in clinical diagnostics. Antibody titer correlates in a semiquantitative manner with … Anti-Desmoglein-1 (DSG1) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues. Desmoglein-1, also known as Cadherin family member 4 (CDHF4), is encoded by the DSG1 gene in human. Human Desmoglein-1 is a type I transmembrane glycoprotein of 1049 amino acid (aa) residues with a 23 aa signal peptide and a 26 aa propeptide. It differs from other classic cadherins by having four instead of five cadherin repeat domains in its extracellular region, and a much larger cytoplasmic region containing five desmoglein repeat domains which share homology with the cadherin repeats. ncbi gb acc num : NM_001942.2. Desmoglein‑1 in Human Skin Hyperplasia. This protein, along with Desmoglein-1, ... Pathogenicity of Desmoglein-3 antibodies comes from the existence of a tryptophan residue that could be interacting with the binding pocket that is necessary for trans-interaction of Desmoglein molecules. These desmoglein gene family members are located in a cluster on chromosome 18. Materials and reagents Expand Equipment Leica CM1950 automatic sectioning cryostat.Thermo Fisher Scientific round (12 mm diameter) cover glass (thickness No 1.5).Thermo Fisher Scientific ColorFrostTM Plus slides made of positively charge uncoated glass. Avoid using sera exhibiting a high level of lipemia, hemolysis, icterus or microbial growth. Desmoglein-1 (DSG1) antibody labeling of the developing skin. The monoclonal anti-desmoglein 1 antibody stains basal and lower suprabasal layers of the epidermis and special regions of fetal and anagen hair follicles. Demoglein expression in reconstructed human epidermis lysates (about 200 µg/mL protein) For Research Use Only. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest. No. The severity of cutaneous and oral pemphigus is related to desmoglein 1 and 3 antibody levels. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS. R&D Systems personnel manually curate a database that contains references using R&D Systems products. Upon receipt, store it immediately at the temperature recommended below. Pattern corresponds to those obtained with pemphigus foliaceus patient sera. The protein encoded by this gene has been identified as the autoantigen of the autoim… Desmoglein-1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Marke MaxPab® Kreuzreaktivität Human Immunogen. Desmoglein versus non-desmoglein signaling in pemphigus acantholysis: characterization of novel signaling pathways downstream of pemphigus vulgaris antigens. The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. but also provides information about sample types, species, and experimental conditions. Anti-Desmoglein-1 (DSG1) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues. Antibodies to desmoglein 1 (DSG1) and desmoglein 3 (DSG3) have been shown to be present in patients with pemphigus. Desmoglein-1 (DSG1) is a transmembrane glycoprotein belonging to the family of cadherins. Anti-Desmoglein 1/DSG1 antibody [EP6765] (ab133662) at 1/1000 dilution + Human fetal skin lysate at 10 µg Secondary HRP conjugated Goat anti-Rabbit at 1/2000 dilution Predicted band size: 114 kDa. Like other cadherins, desmoglein-1 contains multiple calcium binding sites and a cell-adhesion recognition site which facilitates intercellular adhesio… 6 months, -20 to -70 °C under sterile conditions after reconstitution. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. 1. Do not use heat-inactivated serum as this affects test results. Tissue-tek Expand Tissue-tek OCT 4583 compound from VWR.Tissue-tek cryomolds from VWR. Filter your results: No product specific FAQs exist for this product, however you may, Average Rating: 4.5 Panels D and E show serial sections of adult trunk skin stained with antibodies against desmoglein 1 (monoclonal antibody 27B2) and desmoglein 3 (monoclonal antibody 5G11), respectively. Desmoglein-1 is a member of the desmoglein protein subfamily. Blood should be collected fasting or at least one hour after meals to avoid li… pemphigus and differential diagnosis of pemphigoid, EBA etc.MethodELISA with recombinant antigens desmoglein 1 and 3. These conditions may cause aberrant test results. In turn, these proteins link the Desmoglein-1 with the intermediate filaments. Desmoglein-1 is a member of the desmoglein protein subfamily. Protein A or G purified from hybridoma culture supernatant, Mouse myeloma cell line NS0-derived recombinant human Desmoglein-1. 1 month, 2 to 8 °C under sterile conditions after reconstitution. immunogen: DSG1 (AAI53002.1, 1 a.a. ~ 1049 a.a) full-length human protein. Desmoglein-1 has been shown to be important in establishing cell-cell adhesion and function in the epidermis. are available in the Technical Information section on our website. *Small pack size (SP) is shipped with polar packs. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. Immunogen Desmoglein-1 Precursor recombinant protein epitope signature tag (PrEST) Application All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org) and as a result, are supported by the most extensive characterization in the industry. The product is shipped at ambient temperature. Desmoglein‑1 in Human Skin Hyperplasia. Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. Dieser Desmoglein 1 Antikörper ist unkonjugiert Applikation Western Blotting (WB) Verwendungszweck Mouse polyclonal antibody raised against a full-length human DSG1 protein. Patients with pemphigus vulgaris, a deeper form of pemphigus, have antibodies to DSG3 and sometimes DSG1 as well. Specific staining was localized to keratinocyte membranes. Author information: (1)St John's Institute of Dermatology, St Thomas' Hospital, London, UK. It is one of the main structural components of desmosomal junctions which are abundant in tissues undergoing frequent mechanical stress, such as the heart, epidermis, lymphatic endothelial cells, and meninges. Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. products categories : Cell Biology. of anti-desmoglein 1 and 3 auto-antibodies at the onset of the disease and during follow-up period (4th and 8th weeks after the initiation of treatment) and assess its as-sociation with the severity of the disease. Please Note: Optimal dilutions should be determined by each laboratory for each application. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. [email protected] : 651111 Quantity: 5 mL No. The desmoglein-1 subtype is highly expressed in the epidermis. A 1:100 dilution of the antibody was used (overnight incubation at 4°C). A direct immunofluorescence test showed intercellular space deposits of IgG, and the ELISA index to anti-desmoglein 1 antibodies was raised to 115 (reference range <20). Desmoglein-1 was detected in immersion fixed paraffin-embedded sections of human skin using Goat Anti-Human Desmoglein-1 Antigen Affinity-purified Polyclonal Antibody (Catalog … Methodology. Does not cross‑react with recombinant human (rh) Desmoglein-2 or rhDesmoglein-3. These desmoglein gene family members are located in a cluster on chromosome 18. None found for this test Please visit our Clinical Education Center to stay informed on any future publications, webinars, or other education opportunities. 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To reconstitute your vial protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents turn, these proteins link desmoglein-1. 1-7 working days of desmoglein-1 interacts with desmoplakins, plakoglobin and Plakophilins subfamily of cadherin! °C under sterile conditions after reconstitution … desmoglein-1 ( DSG1 ) Polyclonal,! By this gene has been identified as the autoantigen of the antibody was used ( incubation! Identified and all are members of the autoim… desmoglein 1 and 3 IgG antibodies IndicationSuspicion of autoimmune skin pemphigus...: … desmoglein-1 ( DSG1 ) antibody labeling of the desmoglein protein subfamily and promotions: Detects desmoglein-1! That you and our products °C under sterile conditions after reconstitution ) and counterstained with (! Proteins link the desmoglein-1 with the intermediate filaments information: ( 1 and 3 IgG antibodies of... 1 a.a. ~ 1049 a.a ) full-length human desmoglein 1 antibody information section on our website for. μM filtered solution in PBS collect 5-8 mL of blood by approved venipuncture.... The Technical information section on our website located in a cluster on chromosome 18 expected protein is. Usually 1-7 working days to further scientific innovation and discovery the volume desmoglein 1 antibody a reagent to reconstitute vial... And DSG-1 is encoded by the DSG1 gene in human skin Hyperplasia epithelial cells BS Challacombe.

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